Major | College | Number enrolled |
| 1. Political science | Arts & Letters | 569 |
| 2. Psychology | Arts & Letters | 455 |
| 3. English | Arts & Letters | 377 |
| 4. Finance | Business | 348 |
| 5. Science/pre-professional* | Science | 341 |
| 6. Accountancy | Business | 303 |
| 7. History | Arts & Letters | 283 |
| 8. Marketing | Business | 255 |
| 9. Biological sciences | Science | 241 |
| 10. Anthropology | Arts & Letters | 209 |
Source: Notre Dame Institutional Research
*Arts & Letters formerly offered a pre-professional studies (often called pre-med) major. That has now become a supplementary major, meaning that a student must complete the requirements for one of the college's 30 full majors in addition to this sequence. The pre-professional studies supplementary major currently enrolls 472 students.